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KMID : 0525619970020010057
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1997 Volume.2 No. 1 p.57 ~ p.65
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Effect of in vitro Inhibition of Uptake and Promotion of Excretion in Mice on Radiostrontium by Water - soluble Chitosan Derivative
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김희경/Kim HK
이정석/송해미/조만기/조덕제/이응호/Lee JS/Song HM/Cho MG/Cho DJ/Lee EH
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Abstract
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The purpose of this study is to evaluate the effect of water-soluble phosphorylated chitosan(WSPC) on the absorption and the excretion of radiostrontium(85Sr). By the analysis of column chomatography, the absorption of 85Sr to WSPC was 100% at PH 5 and 7(25℃),and 97.8% at pH 3(25℃). For evaluting the excretive effect of WSPC to 85Sr, 11-week old male ICR mice were used and divided into four groups; group A was only treated with 85Sr(0.2yci/head) as controls, and the other groups administrated with 0.01%(B), 0.1%(C), 1%(D) WSPC(1ml/head) immediately after the inoculation of 85Sr (0.2yCi/head) by intragastric route, respectively. Five mice in each group were allocated and were periodically collected their feces and urines from 1 hour to 6 days after the inoculation for examining the quantity of 85Sr. At 6 days of postinoculation(pi), all mice were sacrificed and were sampled from 6 bones(spine, skull, femur, tibia, tooth and tail) for counting the radioactivity of 85Sr. Fecal and urinary excretion of 85Sr was significantly higher in groups B, C and D compared with that in group A during 24 hours pi(P<0.05). Among them group D showed the highest excretive effect in feces and urines than groups B and C (P<0.05). In addition, bony retention of 85Sr in groups B, C and D were significantly lower than that in group A (P<0.01). In conclusion, we suggest that WSPC could be used as an effective agent for the inhibition of uptake and promotion of excretion of 85Sr from animals as well as human beings.
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KEYWORD
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